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Tools for supporting solution scattering during the COVID-19 pandemic.

Lin Yang¹, Edwin Lazo¹, James Byrnes¹

¹Brookhaven National Laboratory, 745 Brookhaven Avenue, Upton, NY 11973, USA.

Journal of Synchrotron Radiation

|July 2, 2021

Summary

Synchrotron beamlines adapted to COVID-19 restrictions by developing new mail-in protocols and software for solution scattering measurements. This innovation ensures data quality and accessibility for remote users, overcoming access barriers.

Keywords:

automation mail-in solution scattering

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Area of Science:

Biophysics
Structural Biology
Materials Science

Background:

COVID-19 pandemic limited access to synchrotron facilities, hindering routine scientific measurements.
The Life Science X-ray Scattering (LiX) beamline faced challenges in providing user access for solution scattering experiments.

Purpose of the Study:

To develop new instrumentation and mail-in protocols to enable solution scattering measurements despite restricted user access.
To create automated software tools for data quality assurance and processing in a remote, low-interaction setting.

Main Methods:

Implemented new instrumentation and mail-in protocols at the LiX beamline.
Developed automated software for data processing and quality assessment.
Leveraged existing infrastructure and aligned with NSLS-II's remote measurement initiatives.

Main Results:

Successfully removed the access barrier for solution scattering measurements.
Ensured data quality and automated data processing adjustments.
Provided initial data assessment summaries for remote users.

Conclusions:

The developed mail-in protocols and software tools effectively enable remote solution scattering measurements.
These advancements maintain scientific productivity and data integrity during pandemic-related access limitations.
The LiX beamline's innovations support broader efforts for remote access at synchrotron facilities.