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Panuveitis following Vaccination for COVID-19
Lucy I Mudie1, Jon D Zick2, Mark S Dacey2
1Sue Anschutz-Rodgers UCHealth Eye Centers, Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Ocular Immunology and Inflammation
|July 2, 2021
Summary
A rare case of panuveitis, an inflammatory eye condition, occurred in a woman after her second Pfizer COVID-19 vaccine dose. Symptoms improved with corticosteroid treatment, suggesting a potential vaccine-related inflammatory event.
Area of Science:
- Ophthalmology
- Immunology
- Vaccinology
Background:
- COVID-19 vaccination has been associated with various inflammatory events.
- This case report focuses on a specific inflammatory ocular condition following vaccination.
Observation:
- A 43-year-old female presented with panuveitis and decreased vision three days post-Pfizer-BioNTech mRNA vaccination.
- Ocular findings included significant choroidal thickening and inflammation in the anterior chamber and vitreous.
- The patient was also diagnosed with asymptomatic COVID-19 infection shortly after symptom onset.
Findings:
- The patient experienced improvement in panuveitis following treatment with oral and topical corticosteroids.
- A mild recurrence of inflammation was noted during an attempt to taper corticosteroid medication.
Implications:
- This case suggests a potential link between the Pfizer-BioNTech mRNA COVID-19 vaccine and the development of panuveitis.
- Further research may be warranted to understand the immunologic mechanisms and incidence of such events.
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