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A delicate initiation: Lipolysis of lipid droplets fuels glioblastoma
1Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Molecular Cell
|July 2, 2021
Abstract:
Liu et al. (2021) demonstrate that CHKα2 is capable of promoting lipolysis of lipid droplets through mechanisms that require sequential steps of post-translational modifications after glucose deprivation. Intriguingly, the oxidation of fatty acids derived from lipid droplets is essential for the survival of tumor cells that informs clinical outcome among glioblastoma patients.

