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Updated: Oct 22, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome

Drew W Grant1, Shengjiang Tan2, Dylan E Ramage1

  • 1Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK.

Molecular Cell
|October 20, 2026
PubMed

Keywords:
AAMPAENC-degronCTLH E3 ligase complexRPL10ZMYND19protein degradationribosome biogenesisuL16ubiquitin-proteasome system

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