Mitochondrial function, dynamics and quality control in the pathophysiology of HFpEF
Andrea Del Campo1, Gonzalo Perez2, Pablo F Castro3
1Laboratorio de Fisiología y Bioenergética Celular, Departamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile.
Summary
Heart failure with preserved ejection fraction (HFpEF) is a complex condition often affecting older adults. Mitochondrial dysfunction plays a key role in HFpEF development, offering potential new therapeutic targets.
Area of Science:
- Cardiology
- Mitochondrial Biology
- Pathophysiology
Background:
- Heart failure (HF) is a major cause of mortality and hospitalization globally.
- HF with preserved ejection fraction (HFpEF) presents diagnostic challenges due to overlapping comorbidities, particularly in the elderly.
- Current therapies for HFpEF lack strong evidence, highlighting the need for deeper pathophysiological understanding.
Purpose of the Study:
- To review the current understanding of mitochondrial network involvement in HFpEF pathogenesis.
- To emphasize the signaling pathways implicated in HFpEF.
- To identify potential future therapeutic targets for HFpEF.
Main Methods:
- Literature review focusing on mitochondrial dysfunction in HFpEF.
- Analysis of signaling pathways linking mitochondria to HFpEF.
- Synthesis of current knowledge on HFpEF pathophysiology.
Main Results:
- Mitochondrial dysfunction is increasingly recognized in HFpEF.
- Mitochondrial dysfunction contributes to systemic inflammation, oxidative stress, endothelial dysfunction, and myocardial remodeling in HFpEF.
- Specific signaling pathways involving mitochondria are implicated in HFpEF progression.
Conclusions:
- Mitochondrial network dysfunction is a significant factor in the pathogenesis of HFpEF.
- Understanding these mitochondrial pathways is crucial for developing effective HFpEF therapies.
- Targeting mitochondrial dysfunction may offer novel therapeutic strategies for HFpEF.
Keywords:
Heart failure with preserved ejection fractionMitochondrial dynamicsMitochondrial metabolismMitophagyMore Related Videos
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