Related Experiment Video

Updated: Oct 30, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.0K

Roles of exosomes-derived lncRNAs in preeclampsia

Rong-Quan Gong1, Abdifatah Mohamed Nuh2, Heng-Shan Cao1

  • 1Yangzhou University Medical College, Yangzhou University, Yangzhou, Jiangsu Province 225009, China.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|July 2, 2021
PubMed

Insights

Preeclampsia biomarkers are lacking. Exosomes carrying long non-coding RNAs (lncRNAs) show potential for early prediction, diagnosis, and treatment of this pregnancy syndrome.

Area of Science:

  • Obstetrics and Gynecology
  • Molecular Biology
  • Biochemistry

Background:

  • Preeclampsia is a serious pregnancy-specific hypertensive disorder with unknown causes and limited diagnostic biomarkers.
  • Accurate diagnosis and effective treatments for preeclampsia remain challenging, impacting maternal and infant safety.

Purpose of the Study:

  • To review the role of exosome-derived long non-coding RNAs (lncRNAs) in preeclampsia.
  • To explore the potential of exosomal lncRNAs as biomarkers for preeclampsia pathogenesis, early prediction, diagnosis, and treatment.

Main Methods:

  • Literature review focusing on exosome biology and lncRNA functions.
  • Analysis of studies reporting differentially expressed lncRNAs in exosomes from preeclampsia patients.
  • Synthesis of current knowledge on exosomal lncRNA structures, functions, and their association with preeclampsia.

Main Results:

  • Exosomes are extracellular vesicles containing bioactive molecules, including lncRNAs.
  • Exosomal lncRNAs are stable, specific, and detectable, making them promising biomarkers.
  • Differentially expressed lncRNAs have been identified in exosomes from preeclampsia placental tissues, suggesting their involvement in the condition.

Conclusions:

  • Exosome-derived lncRNAs offer novel insights into preeclampsia pathogenesis.
  • These molecules hold significant potential for developing new strategies for early prediction, diagnosis, and treatment of preeclampsia.

Keywords:
AngiogenesisExosomesInflammatory immune responseLong non-coding RNAPreeclampsiaTrophoblast

More Related Videos

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

796
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

25.7K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.2K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.0K
Overview of Exosomes01:36

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.0K
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.8K
Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.7K