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A highly sensitive upconversion nanoparticles@zeolitic imidazolate frameworks fluorescent nanoprobe for gallic acid
Yuting Zhang1, Liangmin Ning1, Dameng Gao1
1College of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE), Tianjin Key Laboratory of Metal and Molecule Based Material Chemistry, Collaborative Innovation Centre of Chemical Science and Engineering, Nankai University, Tianjin, 300071, China.
Talanta
|July 3, 2021
Summary
A novel fluorescent nanoprobe using upconversion nanoparticles and ZIF-8 was developed for sensitive gallic acid (GA) detection. This method offers a new approach for analyzing GA in real samples with high accuracy.
Area of Science:
- Nanotechnology
- Analytical Chemistry
- Materials Science
Background:
- Gallic acid (GA) is a significant phenolic compound with various biological activities.
- Accurate detection of GA is crucial for food safety, pharmaceutical analysis, and biological studies.
- Existing detection methods often lack sensitivity or require complex procedures.
Purpose of the Study:
- To design and synthesize a core-shell structured upconversion nanoparticles@zeolitic imidazolate frameworks (ZIF-8) fluorescent nanoprobe.
- To establish a sensitive and selective method for detecting gallic acid (GA) using the developed nanoprobe.
- To investigate the mechanism of GA detection and evaluate its performance in real samples.
Main Methods:
- Synthesis of NaErF4:Tm@SiO2@ZIF-8 core-shell nanoparticles.
- Utilizing the fluorescence quenching and recovery mechanism based on the interaction between oxidized TMB and GA.
- Employing 980 nm laser excitation for upconversion luminescence detection.
- Validation of the method using real sample analysis.
Main Results:
- The NaErF4:Tm@SiO2@ZIF-8 nanoprobe exhibited sensitive fluorescence quenching in the presence of Ag+ and 3,3',5,5'-tetramethylbenzidine (TMB).
- Gallic acid (GA) induced the recovery of fluorescence, enabling its detection.
- The linear detection range for GA was established from 0 to 30 μM, with a limit of detection (LOD) of 0.35 μM.
- The ZIF-8 component significantly enhanced the nanoprobe's sensitivity through physical absorption and electrostatic attraction.
- Successful analysis of GA in real samples demonstrated the practical applicability of the developed fluorescent nanoprobe.
Conclusions:
- A highly sensitive upconversion fluorescence-based method for gallic acid detection has been successfully developed.
- The core-shell NaErF4:Tm@SiO2@ZIF-8 nanoprobe offers a promising platform for the accurate quantification of GA.
- This study represents the first application of upconversion fluorescence for sensitive GA detection, opening new avenues for analytical applications.
