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Updated: Oct 30, 2025

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
Published on: April 8, 2016
The Psoriatic Nonlesional Skin: A Battlefield between Susceptibility and Protective Factors
Evelyn Kelemen1, Renáta Bozó2, Gergely Groma3
1Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Szeged, Hungary; Department of Medical Genetics, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Abstract:
In the last two decades, large-scale gene-expression studies on psoriatic skin samples revealed that even though nonlesional skin is macroscopically identical to healthy skin, it harbors several molecular differences. Originally, these molecular differences were thought to represent susceptibility factors for plaque formation. However, we review in this paper the several factors of immune regulation and structural alteration that are specific for the nonlesional skin and serve as protective factors by counteracting plaque formation and contributing to the maintenance of the nonlesional phenotype.
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