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Related Experiment Video

Updated: Oct 30, 2025

Author Spotlight: Advancing Structural and Biochemical Studies of Proteins Through Thermal Shift Assays
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Small molecule selenium-containing compounds: Recent development and therapeutic applications.

Hongyan Chuai1, San-Qi Zhang1, Huanrong Bai1

  • 1Department of Medicinal Chemistry, School of Pharmacy, Health Science Center, Xi'an Jiaotong University, 76 West Yanta Road, Xi'an, Shaanxi, 710061, PR China.

European Journal of Medicinal Chemistry
|July 3, 2021
PubMed
Summary

Selenium (Se) is an essential micronutrient with therapeutic potential. Organic Se-containing compounds show potent anticancer, antioxidant, and antimicrobial activities, offering a basis for new drug development.

Keywords:
AnticancerAntioxidantApplicationSeSelenoprotein

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Area of Science:

  • Biochemistry and Medicinal Chemistry
  • Nutritional Science
  • Pharmacology

Background:

  • Selenium (Se) is a vital micronutrient crucial for selenoprotein function in organisms.
  • Organic Se-containing compounds are gaining attention for their therapeutic potential against various diseases.
  • Incorporating selenium into small molecules can significantly enhance their biological activities.

Purpose of the Study:

  • To review the research progress and therapeutic applications of Se-containing compounds.
  • To highlight the diverse bioactivities of over 110 selected Se-containing compounds.
  • To provide a foundation for developing novel Se-based therapeutic agents.

Main Methods:

  • Literature review focusing on natural and synthetic organic Se-containing compounds.
  • Classification of compounds based on applications and structural characteristics.
  • Selection of representative compounds demonstrating significant bioactivities.

Main Results:

  • Identified potent anticancer, antioxidant, antifibrolytic, antiparasitic, antibacterial, antiviral, antifungal, and CNS-related effects of Se-containing compounds.
  • Documented the enhanced bioactivities achieved by incorporating selenium into small molecules.
  • Compiled data on over 110 Se-containing compounds with promising therapeutic potential.

Conclusions:

  • Se-containing compounds exhibit a broad spectrum of potent biological activities.
  • Organic selenium compounds represent a promising class of molecules for drug discovery.
  • Further research into Se-containing compounds is warranted for developing new therapeutic strategies.