3D ³¹ P MRSI of the human brain at 9.4 Tesla: Optimization and quantitative analysis of metabolic images

To present ³¹ P whole brain MRSI with a high spatial resolution to probe quantitative tissue analysis of ³¹ P MRSI at an ultrahigh field strength of 9.4 Tesla.

The study protocol included a ³¹ P MRSI measurement with an effective resolution of 2.47 mL. For SNR optimization, the nuclear Overhauser enhancement at 9.4 Tesla was investigated. A sensitivity correction was achieved by applying a low rank approximation of the γ-adenosine triphosphate signal. Group analysis and regression on individual volunteers were performed to investigate quantitative concentration differences between different tissue types.

Differences in gray and white matter tissue ³¹ P concentrations could be investigated for 12 different ³¹ P resonances. In addition, the first highly resolved quantitative MRSI images measured at B₀ = 9.4 Tesla of ³¹ P detectable metabolites with high SNR could be presented.

With an ultrahigh field strength B₀ = 9.4 Tesla, ³¹ P MRSI moves further toward quantitative metabolic imaging, and subtle differences in concentrations between different tissue types can be detected.