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Updated: Oct 30, 2025
06:07
Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
Published on: August 5, 2022
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[Methotrexate use: untangling the real from the fake]
Farah Ahmanna Chakir1, Antoine Folly1, Jean Dudler1
1Clinique de rhumatologie, HFR Fribourg - Hôpital cantonal, 1708 Fribourg.
Revue Medicale Suisse
|July 5, 2021
Summary
This review highlights methotrexate safety for rheumatologists, detailing benefits like subcutaneous administration and folic acid use. It addresses concerns regarding infection and pulmonary fibrosis, aiming to demystify this essential treatment.
Area of Science:
- Rheumatology
- Pharmacology
Background:
- Methotrexate is a cornerstone treatment in rheumatology.
- Non-specialists often have concerns regarding its safety profile.
Purpose of the Study:
- To review key safety aspects of methotrexate for non-specialist clinicians.
- To highlight practical strategies for optimizing methotrexate therapy and patient safety.
Main Methods:
- Review of existing literature and clinical guidelines on methotrexate use.
- Discussion of specific administration routes, adjunct therapies, and safety considerations.
Main Results:
- Methotrexate can be used safely with minimal risk of major infection or pulmonary fibrosis when managed appropriately.
- Subcutaneous administration offers benefits, and low-dose folic acid supplementation is recommended.
- Strategies like co-administration with hydroxychloroquine and temporary cessation for flu vaccination can enhance safety.
Conclusions:
- Methotrexate is a safe and effective treatment when practical management strategies are employed.
- Understanding these elements can demystify methotrexate use for a broader range of healthcare providers.
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