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Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

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The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
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Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

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Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

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Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
207
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

486
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Updated: Oct 30, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Burkitt Lymphoma Presenting as Perforated Appendicitis.

Taylor Shaw1, Hannah Cockrell1, Ramola Panchal1

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|July 5, 2021
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Pediatric appendicitis can rarely be a symptom of Burkitt lymphoma, an aggressive B-cell cancer. This case highlights the importance of considering rare diagnoses in appendicitis presentations.

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Area of Science:

  • Pediatric Surgery
  • Pediatric Oncology
  • Gastroenterology

Background:

  • Appendicitis is a common surgical emergency in children.
  • Primary lymphoma is a rare diagnosis in patients undergoing appendectomy for presumed appendicitis.
  • Burkitt lymphoma, an aggressive B-cell lymphoma, accounts for a significant proportion of these rare lymphoma cases.

Observation:

  • A case report of an adolescent patient initially admitted for perforated appendicitis.
  • The patient presented with symptoms mimicking typical appendicitis.
  • Diagnosis of Burkitt lymphoma was made during the hospital course.

Findings:

  • Appendicitis can be an unusual presentation of intra-abdominal extranodal Burkitt lymphoma.
  • Burkitt lymphoma is characterized by c-Myc gene translocation and dysregulation.
  • Intra-abdominal Burkitt lymphoma can manifest with varied gastrointestinal symptoms.

Implications:

  • This case underscores the need for a broad differential diagnosis in pediatric appendicitis.
  • Early recognition and diagnosis of Burkitt lymphoma are crucial for timely oncologic management.
  • Pathological evaluation of appendectomy specimens is vital for identifying rare malignancies.