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Governing Gene Drive Technologies: A Qualitative Interview Study.

N de Graeff1, Karin R Jongsma1, Jeantine E Lunshof2,3,4

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Summary
This summary is machine-generated.

Expert perspectives on gene drive technologies (GDTs) governance reveal consensus on public engagement but diverging views on its implementation, power dynamics, and decision-making models for these powerful genetic tools.

Keywords:
Ethicsgene drivesgene editinggovernancequalitative research

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Area of Science:

  • Genetics
  • Ecology
  • Bioethics

Background:

  • Gene drive technologies (GDTs) offer potential solutions for challenges like vector-borne diseases by altering inheritance patterns in non-human organisms.
  • Effective governance frameworks are crucial for the responsible development and deployment of GDTs.
  • Expert opinions, which heavily influence GDT governance, have not been thoroughly investigated.

Purpose of the Study:

  • To explore and contrast the perspectives of GDT experts on the governance of these technologies.
  • To identify key themes and challenges in expert views on GDT governance.

Main Methods:

  • The study involved thematic analysis of interviews with 33 experts from diverse professional backgrounds in GDTs.
  • Pseudonymized transcripts were systematically analyzed to identify recurring viewpoints.

Main Results:

  • Three primary themes emerged: community engagement, power dynamics, and decision-making processes.
  • While experts agreed on the importance of engagement, they differed on its specifics (timing, design, rationale).
  • Complexities surrounding power dynamics, historical injustices, and the legitimacy of external demands in local governance were highlighted, alongside varied opinions on decision-making models for GDT deployment.

Conclusions:

  • Expert insights provide a foundation for designing and evaluating GDT governance strategies.
  • Addressing unresolved normative questions is essential for translating general principles into actionable GDT governance obligations.