A case report of lymphocytic hypophysitis.

Area of Science:

• Endocrinology
• Neurology
• Pathology

Background:

• Lymphocytic hypophysitis (LH) is a rare inflammatory condition affecting the pituitary gland, predominantly in women of reproductive age.
• Due to its rarity, LH is often not considered in the differential diagnosis of sellar masses, leading to delayed or missed diagnoses.

Observation:

• A 37-year-old female presented with headaches and a sellar mass identified on CT imaging.
• Endocrine evaluation revealed panhypopituitarism, prompting surgical intervention for a presumed pituitary adenoma.

Findings:

• Histopathological examination of the resected mass confirmed Lymphocytic Hypophysitis (LH) as the diagnosis.
• The case highlights the importance of considering LH in patients with sellar masses and associated endocrine dysfunction.

Implications:

• This case underscores the necessity of a broad differential diagnosis for sellar lesions.
• Integrating clinical presentation, endocrine status, and atypical MRI findings is vital for the accurate diagnosis of LH.