Related Experiment Video
Updated: Oct 30, 2025
09:02
Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
1.7K
Olfactory Dysfunction in Patients Infected with 2019 Novel Coronavirus
Mehdi Bakhshaee1, Maral Barzegar-Amini2, Zohreh Motedayen3
1Sinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Iranian Journal of Otorhinolaryngology
|July 5, 2021
Summary
Olfactory dysfunction is a common symptom in COVID-19 patients, often appearing with other symptoms. This condition, characterized by smell loss, was more prevalent in females and typically resolved within two weeks.
Area of Science:
- Neurology
- Infectious Diseases
- Otolaryngology
Background:
- Olfactory dysfunction is a recognized symptom of COVID-19.
- Understanding its prevalence and characteristics is crucial for patient management.
Purpose of the Study:
- To investigate the occurrence and features of olfactory dysfunction in COVID-19 patients.
- To analyze the onset, duration, and recovery patterns of smell dysfunction.
Main Methods:
- A longitudinal study of 502 patients with confirmed COVID-19.
- Data collected included demographics, clinical information, and olfactory function using the Visual Analog Scale (VAS).
- Olfactory dysfunction features such as onset, duration, and recovery were assessed.
Main Results:
- 38.4% of COVID-19 patients experienced olfactory dysfunction.
- Sudden onset (58.7%) was common, often concurrent with other symptoms (51.1%).
- Olfactory dysfunction recovered within two weeks in 25.3% of anosmic and 46.8% of hyposmic patients.
Conclusions:
- Olfactory dysfunction is a significant symptom associated with COVID-19.
- The condition appears transient and self-limited, with a higher incidence in females.
Related Concept Videos
01:03Olfactory Receptors: Location and Structure
10.0K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
10.0K
01:20Physiology of Smell and Olfactory Pathway
10.3K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
10.3K
01:25Olfaction
46.4K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
46.4K
01:24Nose and Nasal Cavity
6.2K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
6.2K
01:31Common Respiratory Disorders
1.0K
Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
1.0K
01:20COPD: Pathogenesis and Clinical Features
1.1K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.1K