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Updated: Oct 30, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.2K
Therapeutic challenges in managing pediatric psoriasis.
Yamila Goenaga-Vázquez1, Kyle C Lauck1, Adelaide A Hebert1,2
1Department of Dermatology, UTHealth McGovern Medical School, Houston, TX, United States.
International Journal of Women'S Dermatology
|July 5, 2021
Summary
Pediatric psoriasis treatment faces challenges due to limited options. Current U.S. Food and Drug Administration-approved treatments include three biologics and three topicals, with ongoing research for more effective therapies.
Area of Science:
- Dermatology
- Pediatric Medicine
- Pharmacology
Background:
- Psoriasis affects 20,000 children under 10 annually, with increasing incidence.
- Pediatric psoriasis shares similarities with adult-onset disease.
- Limited treatment options and challenges exist for pediatric psoriasis management.
Purpose of the Study:
- To summarize challenges in treating pediatric psoriasis (age <12).
- To review available treatment options and supporting evidence for pediatric psoriasis.
Main Methods:
- Reviewed American Academy of Dermatology and National Psoriasis Foundation guidelines.
- Analyzed recent studies, clinical trials (FDA-approved and non-approved), case reports, and reviews.
- Examined American and European guidelines and expert panel recommendations.
Main Results:
- Six U.S. Food and Drug Administration-approved medications exist: 3 biologics, 3 topicals.
- Off-label topical treatments show variable effectiveness and safety.
- Adult trial data and pediatric case reports suggest efficacy of other biologics.
Conclusions:
- Clinicians face challenges due to unanswered questions in pediatric psoriasis.
- An overview of current on- and off-label medications is provided.
- Pediatric clinical trials are needed to expand therapeutic options.
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