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A visible-light-induced photocatalyst-free approach for C-3 dicarbonyl coumarin production
Jinhu Xi1, Xinjie Wu, Mengmeng Huang
1College of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, China. ybli@zzu.edu.cn kim@zzu.edu.cn.
Abstract:
A mild and efficient visible-light-induced synthesis of C-3 dicarbonyl coumarins from 3-arylacetylene coumarins without a photocatalyst was reported. This iodide-mediated method exhibited broad substrate scope and good functional group tolerance, and a series of C-3 dicarbonyl coumarins were obtained in moderate to excellent yields. Based on the control experimental results, it was found that the visible-light-induced oxidation might be via both radical and ionic processes. Moreover, some synthesized compounds displayed high sensitivity to hydrogen peroxide (H2O2) with a low detection limit (DL, down to 0.149 μM).
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