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Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Regulation of Stroke Volume01:27

Regulation of Stroke Volume

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
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Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
97
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

119
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
119
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

191
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
191
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

553
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
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COVID-19 and ischemic stroke.

Dimitrios Sagris1, Aikaterini Papanikolaou1, Alexandra Kvernland2

  • 1Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

European Journal of Neurology
|July 5, 2021
PubMed
Summary
This summary is machine-generated.

COVID-19 patients frequently experience thrombotic complications, including ischemic stroke. This review covers COVID-19

Keywords:
COVID-19SARS-CoV-2ischemic strokepathophysiology

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiovascular Medicine

Background:

  • The COVID-19 pandemic has seen a significant rise in thrombotic complications among patients.
  • Ischemic stroke is a notable complication, impacting patient outcomes and healthcare systems.
  • Potential mechanisms include immune responses, renin-angiotensin system alterations, and direct SARS-CoV-2 effects on tissues.

Purpose of the Study:

  • To review the current understanding of ischemic stroke in COVID-19 patients.
  • To bridge the gap between basic science research and clinical practice.
  • To provide insights relevant to managing stroke during the global health crisis.

Main Methods:

  • Literature review of existing studies on COVID-19 and ischemic stroke.
  • Synthesis of epidemiological data, clinical manifestations, and pathophysiological mechanisms.
  • Analysis of challenges in stroke management within the context of the pandemic.

Main Results:

  • COVID-19 is associated with an increased incidence of thrombotic events and ischemic stroke.
  • Multiple interconnected mechanisms contribute to stroke pathogenesis in COVID-19.
  • Healthcare systems faced unprecedented challenges in managing stroke patients during the pandemic.

Conclusions:

  • Understanding the multifaceted nature of ischemic stroke in COVID-19 is crucial.
  • Integrated approaches are needed to address both the viral infection and cerebrovascular complications.
  • This review provides a foundation for improved clinical strategies and future research.