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Updated: Oct 30, 2025

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

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Pseudotumoral Endometriotic Nodule.

Sara Engels¹, Michelle Nisolle², Stavros Karampelas¹

¹Department of Obstetrics and Gynecology (Drs. Engels and Karampelas).

Journal of Minimally Invasive Gynecology

|July 5, 2021

Summary

This case report details a rare instance of endometriosis presenting as a solid adnexal mass. Laparoscopic surgery confirmed and removed the pseudotumoral endometriotic nodule, highlighting its importance in differential diagnosis.

Keywords:

Adnexal mass Endometriosis Laparoscopy

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Area of Science:

Gynecologic Oncology
Surgical Pathology
Reproductive Medicine

Background:

Endometriosis is a complex condition with multifactorial origins, including genetic, environmental, and hormonal influences.
It can manifest with diverse clinical presentations, sometimes mimicking neoplastic processes.
Early and accurate diagnosis is crucial for effective management and patient outcomes.

Observation:

A 44-year-old patient presented with dyspareunia and was diagnosed with a solid adnexal mass.
Imaging studies suggested a solid mass with a 39% risk of malignancy, prompting surgical intervention.
Laparoscopy revealed bilateral normal adnexa but identified a pediculated endometriotic nodule originating from the uterosacral ligament.

Findings:

Histopathological analysis confirmed the mass as a pseudotumoral endometriotic nodule, characterized by vascular stroma with endometriotic foci and glandular epithelium without atypia.
The patient underwent successful laparoscopic excision of the endometriotic nodule en bloc with the uterosacral ligaments.
Postoperative recovery was uneventful, with the patient discharged within 24 hours.

Implications:

This case underscores the importance of considering endometriosis in the differential diagnosis of solid adnexal masses, particularly in symptomatic patients.
Laparoscopic techniques allow for precise diagnosis and minimally invasive treatment of such rare presentations.
Recognizing pseudotumoral endometriosis is vital to avoid misdiagnosis and unnecessary radical procedures.