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Updated: Oct 29, 2025

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse POP Quantification System
Published on: September 20, 2018
Premenstrual dysphoric disorder is associated with the longer length from clitoris to urethra
Zheng Li1,2, Meng-Jiao Xu2, Ying Jin1
1Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, 200124, China.
Background:
Premenstrual dysphoric disorder (PMDD) is a common, recently recognized, psychiatric condition among reproductive women, reflecting abnormal responsivity to ovarian steroids. Moreover, the potential organizational effect of prenatal sex hormones during PMDD has got attentions, but there have been considerably less of researches on this topic. The aim of this research was to investigate the possible role of prenatal androgen in the PMDD.
Methods:
Anogenital distance (AGD), the distance between a woman's clitoris and her urethral meatus (CUMD), left and right 2D:4D ratios were measured in 77 subjects (25 patients with PMDD), as these anthropometric indicators are considered to indirectly reflect prenatal androgen exposures in utero.
Results:
Patients with PMDD had a longer CUMD than controls (25.03 ± 4.73 vs. 22.07 ± 4.30, P = 0.008), while there were no significant difference between PMDD group and control group in the AGD and right and left 2D:4D ratios.
Conclusion:
Atypical high prenatal androgen exposure might predispose individuals to be susceptible to PMDD.
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