Related Experiment Videos
"Masked" Philadelphia chromosome resulting from a t(X;22) in chronic myeloid leukemia
G Barbata1, P Carbone, M C Giglio
1Dipartimento di Biologia Cellulare e dello Sviluppo A. Monroy, Sezione di Genetica, Università di Palermo, Italy.
Cancer Genetics and Cytogenetics
|February 1, 1988
Abstract:
A rare cytogenetic finding in chronic myeloid leukemia is reported. It consisted in a "masked" Philadelphia chromosome, resulting from an unusual translocation between chromosomes #22 and X. The t(X;22) was present in 100% of direct and cultured bone marrow cell preparations. Chromosome #9 did not seem to be involved in the formation of the Ph marker. Involvement of the X chromosome in karyotypic changes of hematologic diseases, with particular respect to chronic myeloid leukemia, is discussed.