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Published on: April 28, 2015
Eu3+-doped layered gadolinium hydroxides as drug carriers and their bactericidal behavior
Baiyi Shao1, Xiaobao Zhang2, Aoping Guo2
1Beijing Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, 19-Xinjiekouwai Street, Haidian District, Beijing 100875, China; Qian Xuesen Laboratory of Space Technology, China Academy of Space Technology, 104-Youyi Road, Haidian District, Beijing 100094, China.
Abstract:
Layered rare earth hydroxides (LRHs) due to outstanding photoluminescence (PL) properties and anion exchangeability are extensively reported in multiple fields. In this work, the drug-loaded and bactericidal behaviors of Eu3+-doped layered gadolinium hydroxides (LGdHs:Eu) as optical carriers were explored through intercalation and release of cephalexin (CE). In the intercalation state, the PL intensity of CE--LGdHs:Eu obviously decreased because of the quenching effect of CE-. And the PL intensity of LGdHs:Eu was restored with the release of CE- ions in phosphate buffer solutions (PBS). A significant functional relationship between the drug releasing amount and PL intensity ratio was found, providing a novel optical method to specify the drug dosage. And CE--LGdHs:Eu showed the excellent bactericidal properties in both in vivo and in vitro experiments.
