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Updated: Oct 29, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Protein Causes of Urticaria and Dermatitis
Alyssa Gwen Ashbaugh1, Mary Kathryn Abel2, Jenny E Murase3
1Department of Dermatology, University of California, San Francisco, Third and Fourth Floors, 1701 Divisadero St, San Francisco, CA 94115, USA; School of Medicine, University of California, Irvine, 1001 Health Sciences Rd, Irvine, CA 92617, USA.
Abstract:
Protein contact dermatitis is a cutaneous hypersensitivity reaction after chronic, recurrent exposure or chronic irritation to animal or plant protein. Although the pathophysiological mechanisms underlying protein contact dermatitis are not well characterized, protein contact dermatitis is thought to be caused by combined type I/IV-mediated, type-1 mediated, or a Langerhans cell immunoglobulin E-mediated delayed hypersensitivity reaction. This chapter reviews the epidemiology, pathogenesis, clinical features, common protein allergens, diagnostic process, treatment options, and prognosis of protein contact dermatitis.
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