Related Experiment Video
Updated: Oct 29, 2025

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
Ventilator-associated pneumonia due to carbapenem-resistant Providencia rettgeri
Nupur B Patel1, Gaurav Jain2, Saurabh Chandrakar2
1Department of Anesthesia and Critical Care, AIIMS Rishikesh, Rishikesh, India nupurbpatel@yahoo.co.in.
Abstract:
Ventilator-associated pneumonia (VAP) is one of the leading cause of mortality and morbidity in critically ill patients on mechanical ventilation. We report a case of VAP caused by Providencia rettgeri in a postoperative 58-year-old man with prepyloric perforation. The patient's ICU stay was complicated by VAP. As the organism was carbapenem resistant, high-dose extended infusion of meropenem along with cefepime was started. Early identification and treatment helped in successful weaning of the patient from the ventilator. Providencia is an emerging nosocomial pathogen with an increase in resistance pattern. This case highlights the rarity and importance of Providencia as a cause of VAP.
Insights
Ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Providencia rettgeri is rare but serious. Prompt treatment with antibiotics led to successful patient recovery and ventilator weaning.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Microbiology
Background:
- Ventilator-associated pneumonia (VAP) is a significant cause of mortality in critically ill patients requiring mechanical ventilation.
- Providencia species are increasingly recognized as nosocomial pathogens, often exhibiting antimicrobial resistance.
Observation:
- A 58-year-old male patient developed VAP following surgery for prepyloric perforation.
- The VAP was caused by carbapenem-resistant Providencia rettgeri.
Findings:
- The patient received high-dose extended infusion meropenem and cefepime due to the carbapenem resistance.
- Early diagnosis and appropriate antimicrobial therapy facilitated successful patient recovery and liberation from mechanical ventilation.
Implications:
- This case underscores the importance of considering Providencia species in VAP, especially in the context of rising antimicrobial resistance.
- Highlights the need for vigilant surveillance and prompt management of VAP caused by emerging resistant pathogens.
More Related Videos
04:32Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
09:17A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
Published on: January 2, 2017
Related Concept Videos
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia III: Complications and Assessment
Pneumonia II: Pathophysiology
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...