Selective Estrogen Receptor Modulators: A Potential Option For Non-Binary Gender-Affirming Hormonal Care?

Area of Science:

• Endocrinology
• Gender-affirming care
• Pharmacology

Background:

• Gender dysphoria causes distress due to incongruence between gender identity and birth-assigned sex.
• Medical transition, including hormonal therapy, is a common treatment for gender dysphoria.
• Current hormonal guidelines primarily serve binary transitions (male-to-female or female-to-male).

Purpose of the Study:

• To explore the theoretical use of Selective Estrogen Receptor Modulators (SERMs) for non-binary individuals assigned male at birth (AMAB).
• To address the lack of hormonal options for non-binary individuals seeking an androgynous appearance.
• To investigate SERMs for partial feminization without inducing breast growth.

Main Methods:

• Discussion of the theoretical application of SERMs.
• Review of existing knowledge on SERMs' pharmacodynamic effects.
• Consideration of potential gender-affirming outcomes and adverse effects.

Main Results:

• SERMs may offer a novel approach for gender affirmation in non-binary AMAB individuals.
• Partial feminization without breast growth is a theoretical possibility with SERMs.
• Significant knowledge gaps exist regarding SERM use and safety in this population.

Conclusions:

• SERMs present a potential, yet under-researched, hormonal treatment option for non-binary AMAB individuals seeking androgyny.
• Further investigation into SERMs' efficacy and safety is crucial for this specific patient group.
• Addressing the limited hormonal options for non-binary gender affirmation is a critical area for future research.