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Eruptive agminated nevi in a successfully treated Langerhans cell histiocytosis patient
Maria Echavarria1, Jennifer Schoch2, Jesalyn Tate2
1Department of Pediatrics, University of Florida, Gainesville, FL, USA.
Abstract:
A 7-year-old girl with a history of Langerhans cell histiocytosis (LCH), in remission, presented with the sudden appearance of multiple, agminated nevi. Skin biopsy revealed a benign junctional nevus, without recurrence of LCH. Subsequent immunohistochemical testing of both the skin and iliac wing biopsies demonstrated a BRAF V600E mutation. MAPK pathway mutations have been implicated in both LCH and nevogenesis.
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