Related Experiment Video
Updated: Oct 29, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Iridium-catalysed branched-selective hydroacylation of 1,3-dienes with salicylaldehydes
1Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Rd, Shanghai, 200062, China. dxing@sat.ecnu.edu.cn.
Abstract:
Herein, we report an iridium-catalyzed branched-selective hydroacylation of 1-aryl 1,3-dienes with salicylaldehydes under mild conditions with no need of phosphine ligands. With this protocol, a series of α-branched β,γ-unsaturated o-hydroxyacetophenones with biological potentials were synthesized in high efficiency with excellent regioselectivities. When simple 1,3-butadiene or isoprene instead of 1-aryl 1,3-dienes were used, exclusive linear-selective hydroacylation products were obtained.
More Related Videos
09:54Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes
Published on: September 12, 2018
12:27Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Related Concept Videos
Electrophilic 1,2- and 1,4-Addition of HX to 1,3-Butadiene
Alkynes to Aldehydes and Ketones: Hydroboration-Oxidation
One of the convenient methods for the preparation of aldehydes and ketones is via hydration of alkynes. Hydroboration-oxidation of alkynes is an indirect hydration reaction in which an alkyne is treated with borane followed by oxidation with alkaline peroxide to form an enol that rapidly converts into an aldehyde or a ketone. Terminal alkynes form aldehydes, whereas internal alkynes give ketones as the final product.
Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene
Radical Anti-Markovnikov Addition to Alkenes: Overview
Regioselectivity and Stereochemistry of Hydroboration
Hydroboration proceeds in a concerted fashion with the attack of borane on the π bond, giving a cyclic four-centered transition state. The –BH2 group is bonded to the less substituted carbon and –H to the more substituted carbon. The concerted nature requires the simultaneous addition of –H and –BH2 across the same face of the alkene giving syn...
Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration