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SUMO paralogue-specific functions revealed through systematic analysis of human knockout cell lines and gene

Danielle Bouchard1, Wei Wang1, Wei-Chih Yang1

  • 1Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205.

Molecular Biology of the Cell
|July 7, 2021
PubMed
Summary

Small ubiquitin-related modifiers (SUMOs) are crucial for cellular functions. This study reveals unique roles for SUMO1 and SUMO2 in maintaining cell structure, stress response, and gene expression, highlighting their nonredundant functions.

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