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Lactobacillus johnsonii Alleviates Immune Checkpoint Inhibitor-Associated Colitis by Modulating Macrophage

Wei Liang1, Shuying He1, Heqing Tao1

  • 1Department of Gastroenterology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong 510120, China.

Journal of Agricultural and Food Chemistry
|July 13, 2026
PubMed
Summary

Lactobacillus johnsonii administration mitigated immune checkpoint inhibitor (ICI)-associated colitis by modulating immune cells and promoting gut barrier function. This probiotic also enhanced ICI efficacy in tumor models, suggesting clinical potential.

Keywords:
aryl hydrocarbon receptorgut microbiotaimmune checkpoint inhibitor-associated colitisimmunityprobiotictryptophan metabolism

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