Antimicrobial photodynamic therapy against Acinetobacter baumannii
Adenilson de Souza da Fonseca1, Andre Luiz Mencalha2, Flavia de Paoli3
1Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Avenida 28 de Setembro, 87, fundos, Vila Isabel, Rio de Janeiro, 20551030, Brazil; Departamento de Ciências Fisiológicas, Instituto Biomédico, Universidade Federal do Estado do Rio de Janeiro, Rua Frei Caneca, 94, Rio de Janeiro, 20211040, Brazil; Centro de Ciências da Saúde, Centro Universitário Serra dos Órgãos, Avenida Alberto Torres, 111, Teresópolis, Rio de Janeiro, 25964004, Brazil.
Antimicrobial photodynamic therapy (aPDT) shows promise against multidrug-resistant Acinetobacter baumannii. Further clinical studies are needed to confirm its effectiveness and assess potential bacterial selective pressure.
Area of Science:
- Microbiology
- Infectious Diseases
- Photomedicine
Background:
- Acinetobacter baumannii is a significant opportunistic pathogen causing severe infections.
- This bacterium exhibits high resistance to multiple antibiotics, complicating treatment.
- Hospital outbreaks are frequently associated with A. baumannii infections.
Purpose of the Study:
- To review the efficacy of antimicrobial photodynamic therapy (aPDT) against Acinetobacter baumannii.
- To summarize findings on aPDT's potential to overcome antibiotic resistance in A. baumannii.
Main Methods:
- A literature search was conducted on PubMed for studies on aPDT and A. baumannii.
- Findings from selected studies were summarized regarding aPDT's effectiveness.
Main Results:
- Exogenous photosensitizers demonstrate efficacy against multidrug-resistant A. baumannii strains in vitro.
- aPDT is a promising strategy as it does not exert selective environmental pressure on bacteria.
Conclusions:
- aPDT, using various exogenous photosensitizers, is effective against multidrug-resistant A. baumannii in laboratory settings.
- Further research is required to evaluate the clinical applicability and potential for selective pressure induction of aPDT against A. baumannii.
