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Updated: Oct 29, 2025

Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation
Published on: June 20, 2018
Nasal Septal Perforation Due to Desmopressin Nasal Spray Use
Daniela A Brake1, Grant S Hamilton2, Stephen F Bansberg1
1Department of Otolaryngology-Head & Neck Surgery, Mayo Clinic, Phoenix, AZ, USA.
Abstract:
Perforations of the nasal septum have many etiologies and occasionally result from intranasal medicated spray use. This case report describes a perforation related to the use of desmopressin nasal spray, which has not been previously reported in the literature. Clinical considerations presented in this article include appropriate technique of nasal spray application, appropriate monitoring of patients on intranasal sprays, and indications for evaluation by an otolaryngologist. Septal perforation treatment success is improved with an early diagnosis.
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