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Updated: Oct 29, 2025
Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
Published on: May 31, 2017
Bionic microenvironment-inspired synergistic effect of anisotropic micro-nanocomposite topology and biology cues on
Guicai Li1,2,3,4, Tiantian Zheng5,2,3, Linliang Wu5,2,3
1Key laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Nantong University, 226001 Nantong, P.R. China. gcli1981@ntu.edu.cn nervegu@ntu.edu.cn yangym@ntu.edu.cn.
Abstract:
Anisotropic topographies and biological cues can simulate the regenerative microenvironment of nerve from physical and biological aspects, which show promising application in nerve regeneration. However, their synergetic influence on injured peripheral nerve is rarely reported. In the present study, we constructed a bionic microenvironment-inspired scaffold integrated with both anisotropic micro-nanocomposite topographies and IKVAV peptide. The results showed that both the topographies and peptide displayed good stability. The scaffolds could effectively induce the orientation growth of Schwann cells and up-regulate the genes and proteins relevant to myelination. Last, three signal pathways including the Wnt/β-catenin pathway, the extracellular signal-regulated kinase/mitogen-activated protein pathway, and the transforming growth factor-β pathway were put forward, revealing the main path of synergistic effects of anisotropic micro-nanocomposite topographies and biological cues on neuroregeneration. The present study may supply an important strategy for developing functional of artificial nerve implants.
