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Prognostic Value of c-MYC Expression in Patients with Peripheral Neuroblastic Tumors
Feng Zhang1,2,3, Zhuo Tian4, Tinghong Li5,6,7
1Department of Otolaryngology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, People's Republic of China.
Objective:
Neuroblastic tumors are the most common solid tumors in children. The aim of this study was to explore the prognostic value of immunostaining for cellular-myelocytomatosis viral oncogene (c-MYC) expression in patients with peripheral neuroblastic tumors (NTs).
Methods:
A retrospective study was conducted to compare the expression of c-MYC detected by immunohistochemistry and v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) by fluorescence in situ hybridization among 177 cases of NTs and determine the associations of c-MYC and MYCN with the clinical stages, morphological types, and survival rates of NTs.
Results:
The cases positive for c-MYC were mainly the favorable histology type in stage 3 or 4 with a poor NT prognosis, but no morphological changes related to the poor prognosis were observed in their samples under a microscope. The cases with positive c-MYC expression did not overlap those with MYCN amplification.
Conclusion:
Positive c-MYC expression portends a poor prognosis in patients with NTs.
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