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Development and initial characterization of a high-resolution PET detector module with DOI.

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This study developed a compact, high-resolution detector module for organ-dedicated PET systems, achieving excellent energy, timing, and depth of interaction (DOI) resolution for improved medical imaging.

Keywords:
depth of interactionenergy and spatial resolutionlutetium-yttrium oxyorthosilicate (LYSO)positron emission tomographysilicon photomultipliers (SiPM)time

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Area of Science:

  • Medical Imaging Physics
  • Nuclear Instrumentation
  • Positron Emission Tomography (PET) Detector Technology

Background:

  • Organ-dedicated PET scanners offer advantages like higher sensitivity and improved image quality.
  • These systems require detectors with finer pixel sizes and depth of interaction (DOI) capability.

Purpose of the Study:

  • To present a LYSO(Ce) detector module with DOI capability for high-resolution PET systems.
  • To optimize the module configuration for compact housing and maintain signal integrity.

Main Methods:

  • Scaled up a previously developed submodule with LYSO blocks and PETsys TOFPET2 ASIC.
  • Designed a high-speed dual-readout cable for compact dual-readout board integration.
  • Characterized performance (energy, timing, DOI resolution) of LYSO blocks and modules using a 22Na source.

Main Results:

  • Achieved average energy resolution of 16.13% ± 1.01% at 511 keV.
  • Obtained average timing resolution of 658.03 ± 15.18 ps and DOI resolution of 2.62 ± 0.06 mm.
  • Measured in-panel and orthogonal-panel spatial resolutions of 1.9 mm and 4.4 mm at the FOV center.

Conclusions:

  • The developed LYSO(Ce) detector module demonstrates promising performance for high-resolution organ-dedicated PET systems.
  • The optimized design facilitates compact integration and maintains essential detector capabilities.
  • This technology has the potential for advancement in small animal and organ-specific PET imaging.