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Updated: Oct 29, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Acute Liver Failure From Sickle Cell Hepatopathy Treated With Exchange Transfusion
Ahmad N Kassem1, Changsu Park1, Aarthi Rajkumar1
1Internal Medicine, MetroHealth Medical Center, Cleveland, USA.
Abstract:
Sickle cell disease (SCD) is a qualitative hemoglobinopathy that can cause widespread sickling and vaso-occlusive events in all organ systems. Sickle cell hepatopathy is an umbrella term for various acute and chronic pathologies of the liver as a result of sickling in SCD patients. We present below the case of a 49-year-old woman who had an acute liver failure in the setting of a hepatic crisis with recovery after exchange transfusion. Hepatic involvement in SCD may be life-threatening. Understanding the etiology and severity of hepatic involvement by sickling is necessary for appropriate treatment.
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