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Interfacial electrochemical methods focus on the phenomena occurring at the boundary between an electrode and a solution, as opposed to bulk methods that concentrate on the solution's overall properties. These interfacial methods are classified as either static or dynamic based on the presence of a nonzero current in the electrochemical cell and the consistency of analyte concentrations. Static methods, such as potentiometry, measure the cell's potential without any significant current...
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Electrochemical Approach to Measure Physiological Fluid Flow Rates.

Srivats Sarathy1, Marco A Nino1, Abdulsattar H Ghanim2

  • 1Roy J Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, United States.

Frontiers in Chemistry
|July 8, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces a novel electro-dilution method for accurately measuring physiological fluid flow rates. The technique shows promise for reliable in vivo blood flow rate monitoring in critical care and surgery.

Keywords:
ac voltammetryblood flowelectrochemistryelectrodilutionflow measurement

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Fluid Dynamics

Background:

  • Accurate measurement of physiological fluid flow rates, particularly blood flow, is critical for managing critically ill patients and during surgical procedures.
  • Current methods for measuring fluid flow rates often lack the necessary repeatability and reliability for clinical applications.
  • Developing novel, reliable techniques for in vivo flow rate measurement is essential.

Purpose of the Study:

  • To assess the feasibility of an electro-dilution method for measuring fluid flow rates.
  • To evaluate the reliability and repeatability of this novel technique using different mediums.
  • To establish a proof of concept for in vivo physiological fluid flow rate measurement.

Main Methods:

  • Utilized AC voltammetry in an experimental flow loop with an electrochemical cell.
  • Employed a tracer injectate (0.9 wt% saline) into mediums (pure water and anticoagulated blood).
  • Quantified electro-dilution curves using change in current amplitude, total time, and change in total charge across varying AC voltammetry settings.

Main Results:

  • Demonstrated an inverse relationship between all three electro-dilution curve metrics and fluid flow rate for both water and blood.
  • Observed the strongest negative correlation between flow rate and the change in current amplitude.
  • Confirmed the feasibility of the electro-dilution method across different mediums and flow rates.

Conclusions:

  • The electro-dilution method provides a feasible approach for measuring fluid flow rates.
  • The technique shows potential for reliable in vivo measurement of physiological fluid flow rates.
  • Further development could lead to improved clinical monitoring of blood flow in critical care settings.