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Updated: Oct 29, 2025

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

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Datasets exploring putative lncRNA-miRNA-mRNA axes in breast cancer cell lines

Marie-Claire D Wasson1, Justin M Brown1, Jaganathan Venkatesh1

  • 1Department of Pathology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.

Data in Brief
|July 8, 2021
PubMed

Insights

This study identifies novel long non-coding RNA (lncRNA)/microRNA (miRNA)/messenger RNA (mRNA) interactions in breast cancer. These regulatory axes may represent new therapeutic targets for oncogenesis and tumor suppression.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and messenger RNAs (mRNAs) play critical roles in breast cancer development.
  • Dysregulated lncRNA/miRNA/mRNA interactions are implicated in oncogenesis and tumor suppression.
  • Identifying these regulatory axes is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To identify novel regulatory axes involving lncRNAs, miRNAs, and mRNAs in breast cancer.
  • To explore miRNAs regulated by specific oncogenic lncRNAs.
  • To uncover potential therapeutic targets for breast cancer treatment.

Main Methods:

  • Utilized the NCBI Gene Expression Omnibus (GEO) database to analyze microarray datasets.
  • Investigated gene expression changes following lncRNA knockdown in breast cancer cell lines.
  • Analyzed miRNA transcript alterations and predicted their mRNA targets to elucidate lncRNA/miRNA/mRNA axes.

Main Results:

  • Identified four lncRNAs (LincK, LincIN, SPRY4-IT1, AC009283.1) associated with breast cancer.
  • Characterized miRNAs regulated by these specific lncRNAs.
  • Uncovered potential lncRNA/miRNA/mRNA regulatory networks relevant to breast cancer.

Conclusions:

  • Discovered novel lncRNA/miRNA/mRNA interactions in breast cancer.
  • These identified axes offer promising candidates for further investigation into gene regulation.
  • The findings contribute to understanding breast cancer pathogenesis and may guide future therapeutic development.
Keywords:
Breast cancerLong non-coding RNAOncogenesisRegulationmRNAmicroRNA

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