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Updated: Oct 29, 2025
08:05
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
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Biomarkers of asthma
1School of Pharmacy and Biomedical Sciences, Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth, UK - jan.shute@port.ac.uk.
Minerva Medica
|July 8, 2021
Summary
Asthma biomarkers, like FeNO and eosinophils, aid type 2 therapy but have limits. New breath and urine biomarkers show promise for personalized asthma treatment.
Area of Science:
- Pulmonary Medicine
- Biomarker Discovery
- Precision Medicine
Background:
- Biomarkers are crucial for asthma diagnosis, prognosis, and treatment response prediction.
- Current biomarkers like FeNO and blood eosinophils are established for type 2 asthma but have limitations in real-world clinical practice.
- Asthma's complexity and multiple endotypes necessitate novel, validated biomarkers.
Purpose of the Study:
- To review the role and limitations of current asthma biomarkers.
- To explore emerging biomarkers from breathomics and urinary eicosanoid analysis.
- To discuss the potential of these novel biomarkers for precision asthma management.
Main Methods:
- Literature review of established and emerging asthma biomarkers.
- Analysis of data from breathomics (volatile organic compounds) and urinary eicosanoids.
- Discussion of clinical trial outcomes and future research directions.
Main Results:
- Fraction of exhaled nitric oxide (FeNO) and blood eosinophils are key for type 2 asthma therapy response but limited in routine care.
- Breathomics identified volatile organic compounds (VOCs) as potential biomarkers for airway inflammation and treatment adherence.
- Urinary eicosanoids show potential for distinguishing type 2 and non-type 2 inflammation.
Conclusions:
- Existing biomarkers for type 2 asthma have limitations in real-world application.
- Emerging biomarkers from exhaled VOCs and urinary eicosanoids offer new avenues for precision asthma treatment.
- Further clinical validation and point-of-care instrumentation are needed for widespread adoption of novel asthma biomarkers.
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