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Updated: Oct 29, 2025

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Seed Amplification Assay to Diagnose Early Parkinson's and Predict Dopaminergic Deficit Progression

Luis Concha-Marambio1, Carly M Farris1, Bret Holguin1

  • 1R&D Unit, Amprion Inc., San Diego, California, 92121, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|July 8, 2021
PubMed
Abstract

No abstract available in PubMed .

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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