Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

956
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
956
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

6.0K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Not Only Follicular Helper T-Cells but Also Peripheral Helper T-Cells Expanded Correlate With Disease Severity and B-Cell Differentiation in Graves' Disease.

International journal of endocrinology·2026
Same author

The Abnormal Expression of B7-H4 Is Associated With the Pathogenesis of Autoimmune Thyroid Diseases.

Journal of immunology research·2026
Same author

Abnormal Elevation of the Expression of Costimulatory Molecule CD226 in Graves' Disease: Two Cross-Sectional Studies.

Endocrine, metabolic & immune disorders drug targets·2025
Same author

Ketogenic Diet and Endocrine and Metabolic Diseases: A Bibliometric Study and Visualization Analysis.

Endocrine, metabolic & immune disorders drug targets·2024
Same author

16S rRNA Gene Sequencing of Gut Microbiota in Rheumatoid Arthritis Treated with 99Tc-MDP.

Pharmacogenomics and personalized medicine·2024
Same author

Saikosaponin-d Attenuates Hashimoto's Thyroiditis by Regulating Macrophage Polarization.

Journal of immunology research·2022
Same journal

Out of target glycemic control and severe hypoglycemia in older adults with diabetes presenting to the emergency department.

BMC endocrine disorders·2026
Same journal

Participants' experiences of living with cystic fibrosis related diabetes and using a hybrid closed-loop system to support self-management: qualitative study.

BMC endocrine disorders·2026
Same journal

Triglyceride glucose-weight adjusted waist index as a promising predictive marker for incident diabetes: a large-scale retrospective cohort study.

BMC endocrine disorders·2026
Same journal

Trends and disparities in thyroid cancer related mortality from 1999 to 2023: about CDC WONDER database analysis.

BMC endocrine disorders·2026
Same journal

Real-world effectiveness of quadruple oral hypoglycemic therapy in type 2 diabetes patients refusing insulin therapy.

BMC endocrine disorders·2026
Same journal

Association between HbA1c and red cell distribution width-standard deviation in newly diagnosed, treatment-naïve type 2 diabetes mellitus: a retrospective cross-sectional study.

BMC endocrine disorders·2026
See all related articles

Related Experiment Video

Updated: Oct 29, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.0K

Associations between CD160 polymorphisms and autoimmune thyroid disease: a case-control study.

Weiwei He1, Jing Zhao1,2, Xuerong Liu3

  • 1Department of Endocrinology and Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201508, China.

BMC Endocrine Disorders
|July 9, 2021
PubMed
Summary
This summary is machine-generated.

This study found a significant association between the CD160 rs744877 polymorphism and Graves' disease, suggesting its role in autoimmune thyroid disease pathogenesis. This genetic link provides new insights into Graves' disease susceptibility.

Keywords:
CD160Graves’ diseaseHashimoto’s thyroiditisPolymorphism

More Related Videos

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

2.8K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.8K

Related Experiment Videos

Last Updated: Oct 29, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.0K
A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

2.8K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.8K

Area of Science:

  • Immunogenetics
  • Autoimmune Diseases
  • Molecular Biology

Background:

  • The CD160/HVEM/LIGHT/BTLA signaling pathway is implicated in autoimmune disease pathogenesis.
  • The association between CD160 polymorphisms and autoimmune thyroid disease (AITD) remains unexplored.

Purpose of the Study:

  • To investigate the relationship between CD160 gene polymorphisms and AITD.
  • To evaluate the potential role of CD160 in the development of Graves' disease and Hashimoto's thyroiditis.

Main Methods:

  • Genotyping of CD160 single nucleotide polymorphisms (SNPs) using high-throughput methods in 1017 AITD patients (634 Graves' disease, 383 Hashimoto's thyroiditis) and 856 healthy controls.
  • Logistic regression analyses were performed to calculate odds ratios (ORs) and 95% confidence intervals (95%CIs).
  • Statistical significance was assessed for genotype distribution and allele frequencies, with adjustments for age and gender.

Main Results:

  • A statistically significant association was found between the CD160 rs744877 polymorphism and Graves' disease, particularly under dominant and additive models (P < 0.05).
  • The association of rs744877 with Graves' disease remained significant after adjusting for age and gender.
  • No significant association was observed between rs744877 and Hashimoto's thyroiditis, nor between CD160 rs3766526 and either AITD subtype.

Conclusions:

  • This study is the first to identify an association between CD160 rs744877 and Graves' disease susceptibility.
  • These findings contribute to understanding the genetic basis of Graves' disease.
  • The results underscore the importance of the CD160/HVEM/LIGHT/BTLA pathway in the pathogenesis of Graves' disease.