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Updated: Oct 29, 2025

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Using a nurse-initiated bedside tool to decrease inappropriate testing for Clostridioides difficile in hospital

Amy Lenz¹, Genevieve Davis¹, Hoda Asmar²

¹Adventist Health Simi Valley, Simi Valley, CA, USA.

Journal of Infection Prevention

|July 9, 2021

Summary

This summary is machine-generated.

A bedside screening tool for Clostridioides difficile (C. difficile) infection reduced laboratory testing by 31% and diagnoses by 56%. This intervention helps prevent overdiagnosis and unnecessary treatment.

Keywords:

Clostridioides difficile Clostridium difficile antimicrobial stewardship diarrhoea infection control nursing staff

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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

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Published on: December 10, 2016

Area of Science:

Infectious Diseases
Hospital Administration
Clinical Diagnostics

Background:

Overdiagnosis of Clostridioides difficile (C. difficile) infection leads to increased hospital stays, antibiotic overuse, and higher costs.
Current diagnostic practices may contribute to unnecessary laboratory testing and patient management challenges.

Purpose of the Study:

To evaluate the impact of a paper-based bedside screening tool on C. difficile laboratory testing and diagnosis rates.
To assess the effectiveness of nurse-led C. difficile screening in reducing inappropriate testing.

Main Methods:

A paper-based bedside screening tool was implemented for nurses to guide C. difficile stool testing decisions.
Data on C. difficile stool tests and diagnoses were collected for nine months before and after tool implementation.

Main Results:

A 31% reduction in the mean monthly number of C. difficile tests performed was observed post-implementation (37 to 25).
A 56% reduction in C. difficile infection diagnoses occurred after tool implementation (19 to 8).

Conclusions:

The bedside screening tool successfully decreased inappropriate C. difficile testing and diagnoses when used by nurses.
This low-cost intervention offers significant implications for patient management, infection control, and cost containment, particularly for institutions without EHR decision support.