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A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

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Acoustophoresis in polymer-based microfluidic devices: Modeling and experimental validation.

Fabian Lickert¹, Mathias Ohlin², Henrik Bruus¹

¹Department of Physics, Technical University of Denmark, DTU Physics Building 309, DK-2800 Kongens Lyngby, Denmark.

The Journal of the Acoustical Society of America

|July 9, 2021

Summary

This study presents a 3D finite-element model for microparticle acoustophoresis in polymer microchannels using MHz ultrasound. It identifies optimal resonance modes for efficient particle focusing, comparable to traditional devices.

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Area of Science:

Acoustofluidics
Microfluidics
Biotechnology

Background:

Acoustophoresis enables precise manipulation of microparticles in microfluidic devices.
Traditional devices often use silicon-glass or glass, limiting material choices.
Ultrasound resonances in microfluidic systems are crucial for efficient particle manipulation.

Purpose of the Study:

To develop and validate a 3D finite-element model for acoustophoresis in polymer microchannels.
To investigate the role of whole-system ultrasound resonances for optimizing acoustophoretic performance.
To compare the performance of polymer-based devices with conventional silicon-glass or glass devices.

Main Methods:

A 3D finite-element model was developed for simulating acoustophoresis.
Numerical simulations were performed for microparticles in a polymer microchannel driven by a piezoelectric transducer.
Acoustic focusing experiments were conducted using polystyrene particles in a polymethylmethacrylate (PMMA) chip.

Main Results:

An optimal resonance mode, based on whole-system ultrasound resonances, was identified for enhanced acoustophoresis.
The acoustophoretic performance in the polymer microchannel was comparable to conventional silicon-glass or glass devices.
Experimental validation showed efficient particle focusing (6.6 s) at specific acoustic energy densities (13 J/m³).

Conclusions:

Polymer-based microfluidic devices can achieve high-quality acoustophoretic particle manipulation.
The principle of whole-system ultrasound resonances offers a new approach for optimizing microfluidic acoustics.
This work demonstrates the potential of MHz frequency acoustophoresis in polymer chips for microparticle manipulation.