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Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
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Urinary iodine concentration and radioactive iodine therapeutic response in patients with differentiated thyroid

Yuyan Jiang1, Jiahui Jin2, Jingzheng Fan3

  • 1Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, PR China.

Biomarkers in Medicine
|July 9, 2021
PubMed

Aim: Urinary iodine concentration (UIC) may assess radioactive iodine ablation. Materials & methods: According the 2015 American Thyroid Association guidelines, patients were categorized into low- to intermediate-risk or high-risk groups. The iodine concentration in the morning urine specimens was measured by the ceric ion-arsenious acid method. Results: In the low- to intermediate-risk group (113 cases), nonexcellent response (non-ER) was associated with higher UIC, higher UIC subgroups (p < 0.05), higher pre-ablative stimulated thyroglobulin levels (p < 0.01). In the high-risk group (68 cases), the non-ER rate was higher in the higher pre-ablative stimulated thyroglobulin group (p < 0.01), but not significantly different between the UIC and UIC subgroups (p > 0.05). Conclusion: The non-ER rate was related to UIC in the low- to intermediate-risk group; however, UIC did not affect the non-ER rate in the high-risk group.

Keywords:
differentiated thyroid cancerlow-iodine dietpreablative stimulated thyroglobulinrisk stratificationurine iodine concentration

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