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Peripheral blood stem cell mobilization with pegylated granulocyte colony stimulating factor in children
Dhwanee Thakkar1, Aseem K Tiwari2, Swati Pabbi2
1Department of Pediatric Hematology Oncology and BMT, Medanta The Medicity, Gurgaon, India.
Background And Aim:
We report here our experience of using pegylated granulocyte colony stimulating factor (peg-GCSF) for peripheral blood stem cell (PBSC) mobilization in children.
Methods And Results:
A total of nine children suffering from high-risk/relapsed solid tumors were mobilized with chemotherapy and peg-GCSF (100 microgram/kg single dose). Mean age was 7.7 years (range 2-15 years).The mean time from peg-GCSF administration to PBSC harvest was 9.7 days. Adequate stem cells (median dose 26.9 million/kg) could be harvested in all children by a single apheresis procedure. No major adverse events observed.
Conclusion:
It is feasible and safe to mobilize PBSC with peg-GCSF in children with cancer.
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