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Immunodeficiency Diseases01:25

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Updated: Oct 29, 2025

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
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[Human immunodeficiency virus and lymphoma].

Illias Tazi1, Fatima Zahra Lahlimi1

  • 1CHU Mohamed VI, Université Cadi Ayyad, Faculté de Médecine, Service d'Hématologie Clinique, Marrakech, Maroc.

Bulletin Du Cancer
|July 11, 2021
PubMed
Summary

HIV-associated lymphomas are a major health concern. Effective treatment combines chemotherapy with antiretroviral therapy, improving outcomes for patients with these cancers.

Keywords:
AIDSAntiretroviral therapyHIVHodgkin lymphomaLymphome de HodgkinLymphome non HodgkinienNon-Hodgkin's lymphomaSIDATraitement antirétroviralVIH

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Area of Science:

  • Oncology
  • Infectious Diseases
  • Hematology

Background:

  • Lymphomas are a significant cause of illness and death in individuals with HIV.
  • Common types include diffuse large B-cell lymphoma, Burkitt lymphoma, primary effusion lymphoma, plasmablastic lymphoma, and Hodgkin lymphoma.
  • Treatment decisions depend on lymphoma stage, patient health, HIV status, and immunosuppression levels.

Purpose of the Study:

  • To review the current understanding of HIV-associated lymphomas.
  • To summarize the epidemiology, pathogenesis, pathology, and treatment strategies for these cancers.

Main Methods:

  • Literature review of epidemiological data.
  • Analysis of pathogenetic mechanisms.
  • Summary of current therapeutic approaches.

Main Results:

  • Treatment outcomes for HIV-associated lymphomas have improved.
  • Combined chemotherapy and effective antiretroviral therapy are key to better results.

Conclusions:

  • HIV-associated lymphomas require a multidisciplinary approach.
  • Advances in antiretroviral therapy have significantly impacted lymphoma management and patient survival.