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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.5K

Atherosclerotic Vascular Disease Associated with Chronic Kidney Disease

Matthew J Tunbridge1, Alan G Jardine2

  • 1Nephrology Department, Royal Brisbane and Women's Hospital, Level 9 Ned Hanlon Building, Butterfield Street, Herston, QLD 4029, Australia; University of Queensland, Mayne Medical Building, 288 Herston Road, Herston, QLD 4029, Australia.

Cardiology Clinics
|July 12, 2021
PubMed

Insights

Cardiovascular risk significantly rises with declining kidney function, especially in end-stage renal disease. Slowing renal decline or transplantation are key to reducing cardiovascular disease in chronic kidney disease patients.

Area of Science:

  • Nephrology and Cardiovascular Medicine
  • Renal Disease Pathophysiology
  • Cardiovascular Risk Stratification

Background:

  • Cardiovascular disease (CVD) risk escalates with decreasing glomerular filtration rate (GFR) in progressive renal disease.
  • Hyperlipidemia is a primary risk factor for atherosclerotic vascular disease (ASVD), a common comorbidity in patients with renal impairment.
  • Dyslipidemia patterns and their association with vascular events become less clear as GFR declines.

Purpose of the Study:

  • To examine the relationship between declining GFR and cardiovascular risk in renal disease.
  • To investigate the challenges in managing dyslipidemia and ASVD in advanced chronic kidney disease (CKD).
  • To identify effective strategies for reducing ASVD in CKD patients.

Main Methods:

  • Review of existing literature on GFR, dyslipidemia, and cardiovascular outcomes in renal disease.
  • Analysis of pathophysiological changes in CKD affecting lipid metabolism and vascular health.
  • Evaluation of therapeutic interventions for ASVD in early, advanced, and end-stage CKD.

Main Results:

  • Cardiovascular risk is maximal in end-stage renal disease patients requiring dialysis.
  • Statin therapy demonstrates reduced effectiveness in advanced and end-stage CKD.
  • Coronary interventions carry a greatly increased risk in CKD patients.

Conclusions:

  • Slowing the decline of renal function is a critical strategy to mitigate ASVD in CKD.
  • Renal transplantation offers a means to restore renal function and potentially reduce cardiovascular risk.
  • Management of cardiovascular risk in advanced CKD requires tailored approaches beyond standard lipid-lowering therapies.

Keywords:
AtherosclerosisChronic kidney diseaseRisk factorsVascular disease

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