Related Experiment Video
Updated: Oct 29, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
Inflammation and tumor progression: signaling pathways and targeted intervention
Huakan Zhao1, Lei Wu1, Guifang Yan1
1Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, China.
Inflammation plays a dual role in cancer, promoting tumors or enhancing anti-tumor immunity. Understanding these inflammatory processes is key to developing novel cancer therapies targeting inflammation.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Inflammation critically regulates cancer development and response to therapy, exhibiting dual roles.
- Chronic inflammation often promotes tumor progression and treatment resistance.
- Acute inflammation can stimulate anti-tumor immune responses via dendritic cell maturation and antigen presentation.
Purpose of the Study:
- To review the complex interplay between inflammation and cancer.
- To discuss key signaling pathways, inflammatory factors, and metabolites involved in inflammation.
- To highlight therapeutic strategies that modulate inflammation for cancer treatment.
Main Methods:
- Literature review and synthesis of current research on inflammation in cancer.
- Analysis of signaling pathways (NF-kB, JAK-STAT, TLR, cGAS/STING, MAPK) and inflammatory mediators (cytokines, chemokines, growth factors, inflammasomes, metabolites).
- Overview of emerging therapeutic approaches targeting inflammation in cancer.
Main Results:
- Identified pivotal regulators of inflammation initiation and resolution.
- Detailed the crosstalk between tumor development and inflammatory processes.
- Highlighted the potential of targeting inflammation for cancer therapy.
Conclusions:
- Inflammation is a critical determinant of cancer progression and therapeutic efficacy.
- Multiple molecular and cellular components orchestrate inflammatory responses in cancer.
- Targeting inflammation offers promising avenues for novel cancer treatment strategies.
More Related Videos
07:44Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
08:19Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Related Concept Videos
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
The Tumor Microenvironment
Targeted Cancer Therapies
There are several types of targeted therapies against...
The JAK-STAT Signaling Pathway
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...