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Related Experiment Video

Updated: Oct 29, 2025

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Targeting the eicosanoid pathway in hepatocellular carcinoma.

Anshuli Razdan1,2, Nathan M Main3, Vincent Chiu3

  • 1School of Medicine, Western Sydney University Sydney, NSW, Australia.

American Journal of Cancer Research
|July 12, 2021
PubMed
Summary

Novel therapeutic targets for advanced liver cancer (hepatocellular carcinoma) are needed. This review explores the eicosanoid pathway

Keywords:
Hepatocellular carcinomaNAFLDcirrhosiscyclooxygenasecytochrome P450eicosanoidsfibrosisinflammationlipoxygenasephospholipase A2

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Area of Science:

  • Hepatology and Cancer Biology
  • Molecular Biology and Biochemistry

Background:

  • Hepatocellular carcinoma (HCC) presents a significant global health challenge with high mortality.
  • Advanced HCC stages have limited therapeutic options, with current treatments offering marginal survival benefits and potential toxicity.
  • Chronic liver injury from factors like viral hepatitis, alcohol, and non-alcoholic fatty liver disease (NAFLD) drives inflammation, fibrosis, cirrhosis, and HCC development.

Purpose of the Study:

  • To review the eicosanoid pathway's role in liver disease progression and hepatocellular carcinoma (HCC) development.
  • To elucidate the mechanisms by which eicosanoid pathway members influence liver diseases, focusing on NAFLD, fibrosis, cirrhosis, and HCC.
  • To identify potential therapeutic targets within the eicosanoid pathway for advanced HCC.

Main Methods:

  • Literature review of the eicosanoid pathway.
  • Analysis of the link between the eicosanoid pathway, inflammation, and liver diseases (NAFLD, fibrosis, cirrhosis, HCC).
  • Identification of key eicosanoid pathway components relevant to HCC pathogenesis.

Main Results:

  • The eicosanoid pathway is intricately linked to inflammation and carcinogenesis in the liver.
  • Specific members of the eicosanoid pathway can either promote or inhibit the development of liver diseases and HCC.
  • Understanding these mechanisms highlights the pathway's potential in disease progression.

Conclusions:

  • The eicosanoid pathway represents a promising area for novel therapeutic strategies in advanced HCC.
  • Targeting specific components of this pathway could offer new treatment avenues for patients with limited options.
  • Further research into the eicosanoid pathway's role in liver disease and cancer is warranted.