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Updated: Oct 29, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Cefiderocol Pharmacokinetics in a Patient Receiving Continuous Venovenous Hemodiafiltration

Emir Kobic1, Christian M Gill2, A Brian Mochon3,4

  • 1Department of Pharmacy, Banner University Medical Center, Phoenix, Arizona, USA.

Open Forum Infectious Diseases
|July 12, 2021
PubMed

Insights

Optimizing cefiderocol dosing for patients on continuous renal replacement therapy (CRRT) is crucial. This case study examines cefiderocol pharmacokinetics in a patient with multidrug-resistant Pseudomonas aeruginosa infection undergoing CRRT.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Nephrology

Background:

  • Antimicrobial dosing presents challenges in patients undergoing continuous renal replacement therapy (CRRT).
  • Effective treatment of multidrug-resistant organisms requires careful pharmacokinetic consideration.
  • Pseudomonas aeruginosa infections necessitate robust therapeutic strategies.

Observation:

  • A patient with multidrug-resistant Pseudomonas aeruginosa pneumonia and bacteremia was treated with cefiderocol.
  • The patient received cefiderocol 2 g intravenously every 8 hours as a 3-hour infusion.
  • Continuous venovenous hemodiafiltration (CVVHDF) was administered concurrently.

Findings:

  • The clinical course of the patient was monitored.
  • Cefiderocol pharmacokinetics were evaluated during CVVHDF.
  • This provides insight into cefiderocol elimination and dosing in CRRT.

Implications:

  • Understanding cefiderocol pharmacokinetics in CRRT is vital for effective patient management.
  • This case may inform future dosing guidelines for cefiderocol in critically ill patients with renal impairment.
  • Optimized dosing can improve clinical outcomes for severe infections in CRRT patients.
Keywords:
CRRTCVVHDFantimicrobial dosingcefiderocolcontinuous renal replacement therapypharmacodynamicspharmacokinetics

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