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Related Experiment Video

Updated: Oct 29, 2025

Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System

Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System

Published on: February 10, 2023

Sonodynamic therapy for gliomas.

Adomas Bunevicius¹, Stylianos Pikis¹, Frederic Padilla^2,3

¹Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA.

Journal of Neuro-Oncology

|July 12, 2021

Summary

This summary is machine-generated.

Sonodynamic therapy (SDT) shows promise for treating incurable gliomas. Pre-clinical studies demonstrate its tumoricidal effects and potential for improved survival, with clinical trials now underway.

Keywords:

Focused ultrasound Glioma Sonodynamic therapy

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Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

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Published on: October 27, 2014

Area of Science:

Oncology
Biomedical Engineering
Drug Delivery

Background:

Glioma is a fatal brain tumor lacking effective treatments.
Sonodynamic therapy (SDT) offers a novel therapeutic strategy.
SDT utilizes sonosensitizers activated by ultrasound to induce tumor cell death.

Purpose of the Study:

To review the mechanisms and efficacy of SDT for glioma treatment.
To provide recommendations for future research and clinical applications of SDT in gliomas.

Main Methods:

Literature review of SDT in glioma models.
Searched PubMed/MEDLINE for studies published before January 2021.

Main Results:

Porphyrin and xanthene derivatives are effective sonosensitizers.
SDT mechanisms include reactive oxygen species generation and cell membrane destabilization.
Pre-clinical studies show significant tumoricidal effects and improved survival in glioma models with minimal damage to surrounding brain tissue.

Conclusions:

SDT is a promising pre-clinical treatment for gliomas.
Further research needed to optimize sonosensitizers and ultrasound parameters.
Clinical trials for SDT in glioma patients are initiating.